Cancer-miRNA Regulatory Network

Compendium of miRNA Target Genes

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Cell Fate Commitment (GO:0045165) Genes Targeted by hsa-mir-1321 in B-CLL Leukemia Haslinger Cluster 54 Table contains all genes in the B-CLL Leukemia Haslinger cluster number 54. If a gene harbors a predicted miRNA binding site by one of the three inference methods it is displayed in the final column: M = Weeder-miRvestigator predicted site, P = PITA predicted site and T = TargetScan predicted site. Entrez ID Symbol Description hsa-mir-1321 GO:0045165 10469 TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) [Source:HGNC Symbol;Acc:17316] zzz999 9223 MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 [Source:HGNC Symbol;Acc:946] T 126353 C19orf21 chromosome 19 open reading frame 21 [Source:HGNC Symbol;Acc:27000] T 768 CA9 carbonic anhydrase IX [Source:HGNC Symbol;Acc:1383] zzz999 1289 COL5A1 collagen, type V, alpha 1 [Source:HGNC Symbol;Acc:2209] zzz999 54700 RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:30346] zzz999 6911 TBX6 T-box 6 [Source:HGNC Symbol;Acc:11605] zzz999 Yes 27254 CSDC2 cold shock domain containing C2, RNA binding [Source:HGNC Symbol;Acc:30359] T 29781 NCAPH2 non-SMC condensin II complex, subunit H2 [Source:HGNC Symbol;Acc:25071] T 8289 ARID1A AT rich interactive domain 1A (SWI-like) [Source:HGNC Symbol;Acc:11110] T 5629 PROX1 prospero homeobox 1 [Source:HGNC Symbol;Acc:9459] zzz999 Yes 3356 HTR2A 5-hydroxytryptamine (serotonin) receptor 2A [Source:HGNC Symbol;Acc:5293] T 8239 USP9X ubiquitin specific peptidase 9, X-linked [Source:HGNC Symbol;Acc:12632] zzz999 5989 RFX1 regulatory factor X, 1 (influences HLA class II expression) [Source:HGNC Symbol;Acc:9982] T 9928 KIF14 kinesin family member 14 [Source:HGNC Symbol;Acc:19181] zzz999 9509 ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 [Source:HGNC Symbol;Acc:218] zzz999 4956 ODF1 outer dense fiber of sperm tails 1 [Source:HGNC Symbol;Acc:8113] zzz999 2645 GCK glucokinase (hexokinase 4) [Source:HGNC Symbol;Acc:4195] zzz999 6376 CX3CL1 chemokine (C-X3-C motif) ligand 1 [Source:HGNC Symbol;Acc:10647] zzz999 4037 LRP3 low density lipoprotein receptor-related protein 3 [Source:HGNC Symbol;Acc:6695] T 6373 CXCL11 chemokine (C-X-C motif) ligand 11 [Source:HGNC Symbol;Acc:10638] zzz999 5988 RFPL1 ret finger protein-like 1 [Source:HGNC Symbol;Acc:9977] zzz999 1056 CEL carboxyl ester lipase (bile salt-stimulated lipase) [Source:HGNC Symbol;Acc:1848] zzz999 9437 NCR1 natural cytotoxicity triggering receptor 1 [Source:HGNC Symbol;Acc:6731] zzz999 7512 XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound [Source:HGNC Symbol;Acc:12823] T 8838 WISP3 WNT1 inducible signaling pathway protein 3 [Source:HGNC Symbol;Acc:12771] zzz999 29984 RHOD ras homolog gene family, member D [Source:HGNC Symbol;Acc:670] zzz999 25891 PAMR1 peptidase domain containing associated with muscle regeneration 1 [Source:HGNC Symbol;Acc:24554] zzz999 3700 ITIH4 inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein) [Source:HGNC Symbol;Acc:6169] zzz999 23095 KIF1B kinesin family member 1B [Source:HGNC Symbol;Acc:16636] zzz999 10869 USP19 ubiquitin specific peptidase 19 [Source:HGNC Symbol;Acc:12617] zzz999 54361 WNT4 wingless-type MMTV integration site family, member 4 [Source:HGNC Symbol;Acc:12783] zzz999 Yes 1826 DSCAM Down syndrome cell adhesion molecule [Source:HGNC Symbol;Acc:3039] zzz999 5774 PTPN3 protein tyrosine phosphatase, non-receptor type 3 [Source:HGNC Symbol;Acc:9655] T 4868 NPHS1 nephrosis 1, congenital, Finnish type (nephrin) [Source:HGNC Symbol;Acc:7908] zzz999 2523 FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) [Source:HGNC Symbol;Acc:4012] zzz999 8292 COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase [Source:HGNC Symbol;Acc:2226] T 3714 JAG2 jagged 2 [Source:HGNC Symbol;Acc:6189] zzz999 Yes 9037 SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A [Source:HGNC Symbol;Acc:10736] T 8557 TCAP titin-cap (telethonin) [Source:HGNC Symbol;Acc:11610] zzz999 2733 GLE1 GLE1 RNA export mediator homolog (yeast) [Source:HGNC Symbol;Acc:4315] T 7421 VDR vitamin D (1,25- dihydroxyvitamin D3) receptor [Source:HGNC Symbol;Acc:12679] T 6695 SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 [Source:HGNC Symbol;Acc:11251] T 5409 PNMT phenylethanolamine N-methyltransferase [Source:HGNC Symbol;Acc:9160] zzz999 2980 GUCA2A guanylate cyclase activator 2A (guanylin) [Source:HGNC Symbol;Acc:4682] zzz999 9319 TRIP13 thyroid hormone receptor interactor 13 [Source:HGNC Symbol;Acc:12307] zzz999 5420 PODXL podocalyxin-like [Source:HGNC Symbol;Acc:9171] T 6769 STAC SH3 and cysteine rich domain [Source:HGNC Symbol;Acc:11353] T 8853 ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 [Source:HGNC Symbol;Acc:2721] zzz999 1158 CKM creatine kinase, muscle [Source:HGNC Symbol;Acc:1994] zzz999 8153 RND2 Rho family GTPase 2 [Source:HGNC Symbol;Acc:18315] T 5047 PAEP progestagen-associated endometrial protein [Source:HGNC Symbol;Acc:8573] zzz999 7318 UBA7 ubiquitin-like modifier activating enzyme 7 [Source:HGNC Symbol;Acc:12471] zzz999 11189 CELF3 CUGBP, Elav-like family member 3 [Source:HGNC Symbol;Acc:11967] zzz999 54587 MXRA8 matrix-remodelling associated 8 [Source:HGNC Symbol;Acc:7542] T 10893 MMP24 matrix metallopeptidase 24 (membrane-inserted) [Source:HGNC Symbol;Acc:7172] T 11183 MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 [Source:HGNC Symbol;Acc:6867] zzz999 56288 PARD3 par-3 partitioning defective 3 homolog (C. elegans) [Source:HGNC Symbol;Acc:16051] zzz999 116372 LYPD1 LY6/PLAUR domain containing 1 [Source:HGNC Symbol;Acc:28431] T 5468 PPARG peroxisome proliferator-activated receptor gamma [Source:HGNC Symbol;Acc:9236] zzz999 Yes 4608 MYBPH myosin binding protein H [Source:HGNC Symbol;Acc:7552] T 6665 SOX15 SRY (sex determining region Y)-box 15 [Source:HGNC Symbol;Acc:11196] zzz999 1271 CNTFR ciliary neurotrophic factor receptor [Source:HGNC Symbol;Acc:2170] T 8856 NR1I2 nuclear receptor subfamily 1, group I, member 2 [Source:HGNC Symbol;Acc:7968] T 51090 PLLP plasmolipin [Source:HGNC Symbol;Acc:18553] T 4129 MAOB monoamine oxidase B [Source:HGNC Symbol;Acc:6834] zzz999 26659 OR7A5 olfactory receptor, family 7, subfamily A, member 5 [Source:HGNC Symbol;Acc:8368] T 26103 LRIT1 leucine-rich repeat, immunoglobulin-like and transmembrane domains 1 [Source:HGNC Symbol;Acc:23404] zzz999 3090 HIC1 hypermethylated in cancer 1 [Source:HGNC Symbol;Acc:4909] T 1032 CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) [Source:HGNC Symbol;Acc:1790] zzz999 949 SCARB1 scavenger receptor class B, member 1 [Source:HGNC Symbol;Acc:1664] zzz999 2978 GUCA1A guanylate cyclase activator 1A (retina) [Source:HGNC Symbol;Acc:4678] T 9854 C2CD2L C2CD2-like [Source:HGNC Symbol;Acc:29000] T 79933 SYNPO2L synaptopodin 2-like [Source:HGNC Symbol;Acc:23532] T 10974 C10orf116 chromosome 10 open reading frame 116 [Source:HGNC Symbol;Acc:24043] zzz999 6699 SPRR1B small proline-rich protein 1B [Source:HGNC Symbol;Acc:11260] zzz999 142684 RAB40A RAB40A, member RAS oncogene family [Source:HGNC Symbol;Acc:18283] zzz999 6354 CCL7 chemokine (C-C motif) ligand 7 [Source:HGNC Symbol;Acc:10634] T 23092 ARHGAP26 Rho GTPase activating protein 26 [Source:HGNC Symbol;Acc:17073] T 10753 CAPN9 calpain 9 [Source:HGNC Symbol;Acc:1486] zzz999 201191 SAMD14 sterile alpha motif domain containing 14 [Source:HGNC Symbol;Acc:27312] zzz999 6183 MRPS12 mitochondrial ribosomal protein S12 [Source:HGNC Symbol;Acc:10380] zzz999 345 APOC3 apolipoprotein C-III [Source:HGNC Symbol;Acc:610] zzz999 11261 zzz999 Calcium-binding protein p22 [Source:UniProtKB/Swiss-Prot;Acc:Q99653] zzz999 27285 TEKT2 tektin 2 (testicular) [Source:HGNC Symbol;Acc:11725] zzz999 796 CALCA calcitonin-related polypeptide alpha [Source:HGNC Symbol;Acc:1437] zzz999 8620 NPFF neuropeptide FF-amide peptide precursor [Source:HGNC Symbol;Acc:7901] zzz999 4886 NPY1R neuropeptide Y receptor Y1 [Source:HGNC Symbol;Acc:7956] T 8547 FCN3 ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen) [Source:HGNC Symbol;Acc:3625] zzz999 124222 PAQR4 progestin and adipoQ receptor family member IV [Source:HGNC Symbol;Acc:26386] zzz999 6667 SP1 Sp1 transcription factor [Source:HGNC Symbol;Acc:11205] zzz999 6608 SMO smoothened homolog (Drosophila) [Source:HGNC Symbol;Acc:11119] zzz999 Yes 9480 ONECUT2 one cut homeobox 2 [Source:HGNC Symbol;Acc:8139] T Yes 726 CAPN5 calpain 5 [Source:HGNC Symbol;Acc:1482] zzz999 1967 EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa [Source:HGNC Symbol;Acc:3257] zzz999 171558 PTCRA pre T-cell antigen receptor alpha [Source:HGNC Symbol;Acc:21290] zzz999 2771 GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 [Source:HGNC Symbol;Acc:4385] T 4589 MUC7 mucin 7, secreted [Source:HGNC Symbol;Acc:7518] zzz999 3846 KRTAP5-9 keratin associated protein 5-9 [Source:HGNC Symbol;Acc:23604] zzz999 2939 GSTA2 glutathione S-transferase alpha 2 [Source:HGNC Symbol;Acc:4627] zzz999 115703 ARHGAP33 Rho GTPase activating protein 33 [Source:HGNC Symbol;Acc:23085] zzz999 30848 CTAG2 cancer/testis antigen 2 [Source:HGNC Symbol;Acc:2492] zzz999 8270 LAGE3 L antigen family, member 3 [Source:HGNC Symbol;Acc:26058] zzz999 6340 SCNN1G sodium channel, nonvoltage-gated 1, gamma [Source:HGNC Symbol;Acc:10602] zzz999 10483 SEC23B Sec23 homolog B (S. cerevisiae) [Source:HGNC Symbol;Acc:10702] zzz999 10277 UBE4B ubiquitination factor E4B (UFD2 homolog, yeast) [Source:HGNC Symbol;Acc:12500] T 1908 EDN3 endothelin 3 [Source:HGNC Symbol;Acc:3178] zzz999 651 BMP3 bone morphogenetic protein 3 [Source:HGNC Symbol;Acc:1070] zzz999 2165 F13B coagulation factor XIII, B polypeptide [Source:HGNC Symbol;Acc:3534] zzz999 6736 SRY sex determining region Y [Source:HGNC Symbol;Acc:11311] zzz999 10215 OLIG2 oligodendrocyte lineage transcription factor 2 [Source:HGNC Symbol;Acc:9398] T Yes 3053 SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 [Source:HGNC Symbol;Acc:4838] T 611 OPN1SW opsin 1 (cone pigments), short-wave-sensitive [Source:HGNC Symbol;Acc:1012] zzz999 3752 KCND3 potassium voltage-gated channel, Shal-related subfamily, member 3 [Source:HGNC Symbol;Acc:6239] zzz999 7046 TGFBR1 transforming growth factor, beta receptor 1 [Source:HGNC Symbol;Acc:11772] zzz999 Yes 6538 SLC6A11 solute carrier family 6 (neurotransmitter transporter, GABA), member 11 [Source:HGNC Symbol;Acc:11044] zzz999 116 ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) [Source:HGNC Symbol;Acc:241] T 116832 RPL39L ribosomal protein L39-like [Source:HGNC Symbol;Acc:17094] zzz999 4311 MME membrane metallo-endopeptidase [Source:HGNC Symbol;Acc:7154] T 3898 LAD1 ladinin 1 [Source:HGNC Symbol;Acc:6472] T 30000 TNPO2 transportin 2 [Source:HGNC Symbol;Acc:19998] zzz999 3782 KCNN3 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 [Source:HGNC Symbol;Acc:6292] zzz999 525 ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 [Source:HGNC Symbol;Acc:853] T 27287 VENTX VENT homeobox homolog (Xenopus laevis) [Source:HGNC Symbol;Acc:13639] zzz999 9079 LDB2 LIM domain binding 2 [Source:HGNC Symbol;Acc:6533] zzz999 10050 SLC17A4 solute carrier family 17 (sodium phosphate), member 4 [Source:HGNC Symbol;Acc:10932] zzz999 755 C21orf2 chromosome 21 open reading frame 2 [Source:HGNC Symbol;Acc:1260] T 1369 CPN1 carboxypeptidase N, polypeptide 1 [Source:HGNC Symbol;Acc:2312] zzz999 9563 H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) [Source:HGNC Symbol;Acc:4795] T 7262 PHLDA2 pleckstrin homology-like domain, family A, member 2 [Source:HGNC Symbol;Acc:12385] zzz999 8092 ALX1 ALX homeobox 1 [Source:HGNC Symbol;Acc:1494] zzz999 199731 CADM4 cell adhesion molecule 4 [Source:HGNC Symbol;Acc:30825] zzz999 2692 GHRHR growth hormone releasing hormone receptor [Source:HGNC Symbol;Acc:4266] T 1136 CHRNA3 cholinergic receptor, nicotinic, alpha 3 [Source:HGNC Symbol;Acc:1957] zzz999 57556 SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A [Source:HGNC Symbol;Acc:10738] T 10612 TRIM3 tripartite motif containing 3 [Source:HGNC Symbol;Acc:10064] T 2303 FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) [Source:HGNC Symbol;Acc:3801] zzz999 Yes 1557 CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 [Source:HGNC Symbol;Acc:2621] zzz999 4143 MAT1A methionine adenosyltransferase I, alpha [Source:HGNC Symbol;Acc:6903] T 1559 CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 [Source:HGNC Symbol;Acc:2623] zzz999 9568 GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 [Source:HGNC Symbol;Acc:4507] T 23072 HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 [Source:HGNC Symbol;Acc:22195] zzz999 22947 DUX4L2 double homeobox 4 like 2 [Source:HGNC Symbol;Acc:37267] zzz999 5205 ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 [Source:HGNC Symbol;Acc:3706] T 10281 DSCR4 Down syndrome critical region gene 4 [Source:HGNC Symbol;Acc:3045] zzz999 1816 DRD5 dopamine receptor D5 [Source:HGNC Symbol;Acc:3026] T 54555 DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 [Source:HGNC Symbol;Acc:18684] zzz999 6557 SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporters), member 1 [Source:HGNC Symbol;Acc:10910] T 1406 CRX cone-rod homeobox [Source:HGNC Symbol;Acc:2383] T 84303 CHCHD6 coiled-coil-helix-coiled-coil-helix domain containing 6 [Source:HGNC Symbol;Acc:28184] zzz999 10536 LEPREL2 leprecan-like 2 [Source:HGNC Symbol;Acc:19318] T 81569 ACTL8 actin-like 8 [Source:HGNC Symbol;Acc:24018] zzz999 6519 SLC3A1 solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1 [Source:HGNC Symbol;Acc:11025] zzz999 5802 PTPRS protein tyrosine phosphatase, receptor type, S [Source:HGNC Symbol;Acc:9681] T 11076 TPPP tubulin polymerization promoting protein [Source:HGNC Symbol;Acc:24164] T 9118 INA internexin neuronal intermediate filament protein, alpha [Source:HGNC Symbol;Acc:6057] zzz999 3976 LIF leukemia inhibitory factor (cholinergic differentiation factor) [Source:HGNC Symbol;Acc:6596] zzz999 4879 NPPB natriuretic peptide B [Source:HGNC Symbol;Acc:7940] zzz999 3352 HTR1D 5-hydroxytryptamine (serotonin) receptor 1D [Source:HGNC Symbol;Acc:5289] zzz999 55715 DOK4 docking protein 4 [Source:HGNC Symbol;Acc:19868] zzz999 8793 TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain [Source:HGNC Symbol;Acc:11907] T 2707 GJB3 gap junction protein, beta 3, 31kDa [Source:HGNC Symbol;Acc:4285] zzz999 725 C4BPB complement component 4 binding protein, beta [Source:HGNC Symbol;Acc:1328] zzz999 2697 GJA1 gap junction protein, alpha 1, 43kDa [Source:HGNC Symbol;Acc:4274] zzz999 23769 FLRT1 fibronectin leucine rich transmembrane protein 1 [Source:HGNC Symbol;Acc:3760] zzz999 9612 NCOR2 nuclear receptor corepressor 2 [Source:HGNC Symbol;Acc:7673] T 9949 AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 [Source:HGNC Symbol;Acc:467] T 1417 CRYBB3 crystallin, beta B3 [Source:HGNC Symbol;Acc:2400] zzz999 9001 HAP1 huntingtin-associated protein 1 [Source:HGNC Symbol;Acc:4812] T 899 CCNF cyclin F [Source:HGNC Symbol;Acc:1591] T 1408 CRY2 cryptochrome 2 (photolyase-like) [Source:HGNC Symbol;Acc:2385] T 253190 SERHL2 serine hydrolase-like 2 [Source:HGNC Symbol;Acc:29446] zzz999 8456 FOXN1 forkhead box N1 [Source:HGNC Symbol;Acc:12765] T 7036 TFR2 transferrin receptor 2 [Source:HGNC Symbol;Acc:11762] zzz999 3419 IDH3A isocitrate dehydrogenase 3 (NAD+) alpha [Source:HGNC Symbol;Acc:5384] zzz999 28513 CDH19 cadherin 19, type 2 [Source:HGNC Symbol;Acc:1758] zzz999 2065 ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) [Source:HGNC Symbol;Acc:3431] T 1361 CPB2 carboxypeptidase B2 (plasma) [Source:HGNC Symbol;Acc:2300] zzz999 9782 MATR3 matrin 3 [Source:HGNC Symbol;Acc:6912] zzz999 1852 DUSP9 dual specificity phosphatase 9 [Source:HGNC Symbol;Acc:3076] T 51066 C3orf32 chromosome 3 open reading frame 32 [Source:HGNC Symbol;Acc:24809] zzz999 54469 ZFAND6 zinc finger, AN1-type domain 6 [Source:HGNC Symbol;Acc:30164] zzz999 816 CAMK2B calcium/calmodulin-dependent protein kinase II beta [Source:HGNC Symbol;Acc:1461] zzz999 2915 GRM5 glutamate receptor, metabotropic 5 [Source:HGNC Symbol;Acc:4597] zzz999 27302 BMP10 bone morphogenetic protein 10 [Source:HGNC Symbol;Acc:20869] zzz999 3592 IL12A interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) [Source:HGNC Symbol;Acc:5969] zzz999 8521 GCM1 glial cells missing homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:4197] zzz999 Yes 1261 CNGA3 cyclic nucleotide gated channel alpha 3 [Source:HGNC Symbol;Acc:2150] zzz999 6928 HNF1B HNF1 homeobox B [Source:HGNC Symbol;Acc:11630] T Yes 10202 DHRS2 dehydrogenase/reductase (SDR family) member 2 [Source:HGNC Symbol;Acc:18349] zzz999

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